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6-APB (6-(2-aminopropyl)benzofuran) is a stimulant drug of legal research chemicals of special interest. It is a very similar structure to 3,4-methylenedioxymethamphetamine (MDMA) and its active metabolite 3,4-methylenedioxyamphetamine (MDA). In fact, 6-APB is often commercialized as a legal sort of ecstasy.
6-APB stimulant RC inhibit the dopamine (DA), norepinephrine (NE) and serotonin (5-HT) transporters (DAT, NET and SERT, respectively); and induce transporter-mediated release via DAT, NET, and SERT. 6-APB also show high affinity to 5-HT2B/2C and adrenoreceptors al/2С receptors. Due to these mechanisms of action, it used as stimulant or entactogen.
6-APB can also be seen as 3,4-methylenedioxy-amphetamine (MDA) and 3,4-methylendioxy-methamphetamine (MDMA) analogue regarding a bioisosteric substitution of one oxygen (-O-) in the furan ring by methine (-CH═).
Mechanism of action of 6-APB has some of the following features: a short window of detectability in the blood; initially unknown urinary metabolites; the need of reference standards; and in some cases, the lack of immunoreactivity in the routine urine immunoassays (LAs). However, 6-APB may cross-react with the existing commercial kits.
The immunogen structure used to generate the antibodies against the drugs, largely defines their antibody specificity. To elicit an immune response, large carrier proteins have to be attached to small drugs and this often results in poor specificity toward the region of the 6-APB where the conjugation took place. LAs generally employ antibodies of moderately high specificity for the 6-APB. This approach minimizes undesired cross-reactivity toward endogenous and putrefactive amines in postmortem samples, over-the-counter drugs (e.g., pseudoephedrine, ephedrine) and other structurally related substances.
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