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Adrafinil (Olmifon) is a novel pharmaceutical eugeroic drug developed in France by Louis Lafon Laboratories in the late 1970s. Adrafinil has behavioral activating effects but lacks the unpleasant side effects common to other stimulants. The presence of these unique characteristics to introduce the term eugeroic as a pharmaceutical category, which consists of agents that produce behavioral arousal without amphetamine-like side effects. Clinical studies have demonstrated that in aged people, adrafinil is effective in treating deficits in arousal or vigilance, difficulties in attention, sleep, memory and mild depression. Adrafinil has also been shown to improve deficits associated with problems in voluntary movement.
Despite these potential applications, few behavioral studies have been completed with nonhuman subjects. The majority of research studies have focused on behavioral activating effects of adrafinil. These research studies generally show that adrafinil induces marked and sustained increases in spontaneous movement, particularly in locomotor activity. Increases in activity have been reported in mice, rats, and monkeys. These activity enhancing effects of adrafinil are similar to those produced by psychostimulants, such as amphetamine. Unlike amphetamine, however, adrafinil does not generally induce stereotyped behavior and the effects of adrafinil are not anxiogenic.
The intended human target population is a subgroup of the aged. Nevertheless, to date none of the previously reported animal studies used aged subjects. We originally became interested in adrafinil because of the possibility that it would have behavioral activating effects in senescent canines.
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